Neuroplasticity and Neuromodulation

The Junior Research Group “Neuroplasticity and Neuromodulation” is embedded in the Institute forTranslational Psychiatry (Department of Mental Health at the University of Münster) and investigates the role of structural connectivity (“Connectomics”) alterations in affective disorders and how antidepressive treatments, especially neurostimulation techniques like electroconvulsive therapy (ECT) and transcranial magnetic stimulation (TMS), modulate brain networks and induce neuroplastic effects.


Lab Head: Dr. Jonathan Repple


  • Marius Gruber, M.Sc.
  • Marco Mauritz, M.Sc.
  • Pascal Grumbach, B.Sc.
  • Cand. med. Amelie König
  • Cand. med. Cathrine Thams
  • Cand. med. Hannes Hofmann


  • Theresa Nick
  • Greta Karliczek

For a full list of members of the Institute for Translational Psychiatry including student workers, medical doctoral candidates, and master students see here

Current funding

  • 01/2018: Pilot Project „Structural-Functional Connectomics in Major Depressive Disorder“; IMF (“Innovative Medizinische Forschung”) of the Faculty of Medicine, University of Muenster
  • 07/2019 Research Project “Effects of repetitive transcranial magnetic stimulation on white matter integrity in major depressive disorder.” IMF (“Innovative Medizinische Forschung”) of the Faculty of Medicine, University of Muenster

Selected publications

Repple J, Mauritz M, Meinert S, de Lange S, Grotegerd D, Opel N, Redlich R, Hahn T, Förster K, Leehr EJ, Winter N, Goltermann J, Enneking V, Fingas, SM, Lemke H, Waltemate L, Nenadic I, Krug A, Brosch K, Schmit S, Stein F, Meller T, Jansen A, Steinsträter O, Baune BT, Kircher T, Dannlowski U, van den Heuvel M (in press): Current depression severity and remission status are associated with connectome alterations in major depressive disorder. Molecular Psychiatry. [IF: 12.0]

Opel N, Martin S, Meinert S, Redlich R, Enneking V, Richter M, Goltermann J, Johnen A, Dannlowski U, Repple J (2019): White matter microstructure mediates the association between physical fitness and cognition in healthy, young adults. Nature Scientific Reports. [IF: 4.0]

Repple J, Karliczek G, Meinert S, Foerster K, Grotegerd D, Goltermann J, Redlich R, Arolt V, Baune B, Dannlowski U, Opel N (2019): Variation of HbA1c affects cognition and white matter microstructure in healthy, young adults. Molecular Psychiatry. [IF: 12.0]

Repple J, Zaremba D, Meinert S, Grotegerd D, Redlich R, Förster K, Dohm K, Opel N, Hahn T, Enneking V, Leehr EJ, Böhnlein J, Dzvonyar F, Sindermann L, Winter N, Goltermann J, Kugel H, Bauer J, Heindel W, Arolt V, Dannlowski U. (2019): Time heals all wounds? A 2-year longitudinal DTI study in major depressive disorder. Journal of Psychiatry and Neuroscience 44(4):1-7. [IF: 5.2]

Repple J, Meinert S, Bollettini I, Grotegerd D, Redlich R, Zaremba D, Bürger C, Förster K, Dohm K, Stahl F, Opel N, Hahn T, Enneking V, Leehr EJ, Böhnlein J, Leenings R, Kaehler C, Emden D, Winter NR, Heindel W, Kugel H, Bauer J, Arolt V, Benedetti F, Dannlowski U. (2019): Treatment response to ECT is associated with white matter integrity. Psychological Medicine Apr 23:1-8. [IF: 5.4]

Repple J, Wagels, L, Habel U, Pawliczek C, Schneider F, Kohn N (2018): Sex differences in the neural correlates of aggression. Brain structure and function 223 (9), 4115-4124. [IF: 3.6]

Repple J, Opel N, Meinert S, Redlich R, Hahn T, Winter NR, Kaehler C, Emden D, Leenings R, Grotegerd D, Zaremba D, Bürger C, Förster K, Dohm K, Enneking V, Leehr EJ, Böhnlein J, Karliczek G, Heindel W, Kugel H, Bauer J, Arolt V, Dannlowski U. (2018): Elevated body-mass index is associated with reduced white matter integrity in two large independent cohorts. Psychoneuroendocrinology 91, 179-185. [IF: 4.7]

Repple J, Pawliczek C, Kohn N, Voss B, Siegel S, Schneider F, Habel U (2017): From provocation to aggression: the neural network. BMC Neuroscience 18 (1), 73. [IF: 2.1]

Repple J, Meinert S, Grotegerd D, Kugel H, Redlich R, Dohm K, Zaremba D, Opel N, Buerger C, Arolt V, Heindel W, Deppe M, Dannlowski U (2017): A Voxel-Based Diffusion Tensor Imaging Study in unipolar and bipolar depression. Bipolar Disorders 00:1–9. [IF: 4.5]

For a full list please see:


Dr. med. Jonathan Repple
Tel.: +49 (0)251 / 83-51879
E-Mail: jonathan.repple(at)­ukmuenster(dot)­de

Administration assistance:
Bettina Walden, M.A.

Tel.: +49 (0)251 / 83-56610
E-Mail: bettina.walden@­